Official symbol | PARP1 |
Gene id | 142 |
Organism | Homo sapiens |
Official full symbol | poly(ADP-ribose) polymerase 1 |
Gene type | protein-coding |
Also known as | ADPRT, ADPRT 1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 |
Summary | This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. |
Genomic regions | Chromosome 1 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
PARP1-203 | ENST00000366794.10 | 3978 | 1014aa | Protein coding | CCDS1554 | A0A024R3T8 P09874 | NM_001618.4 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
PARP1-216 | ENST00000677203.1 | 3850 | 971aa | Protein coding | - | - | - | GENCODE basic, |
PARP1-224 | ENST00000678560.1 | 4255 | 100aa | Nonsense mediated decay | - | - | - | - |
PARP1-214 | ENST00000677091.1 | 3768 | 369aa | Nonsense mediated decay | - | - | - | - |
PARP1-221 | ENST00000678144.1 | 3719 | 308aa | Nonsense mediated decay | - | - | - | - |
PARP1-222 | ENST00000678226.1 | 3274 | No protein | Processed transcript | - | - | - | - |
PARP1-215 | ENST00000677189.1 | 2348 | No protein | Processed transcript | - | - | - | - |
PARP1-220 | ENST00000677985.1 | 2285 | No protein | Processed transcript | - | - | - | - |
PARP1-210 | ENST00000676481.1 | 1371 | No protein | Processed transcript | - | - | - | - |
PARP1-202 | ENST00000366792.3 | 553 | No protein | Processed transcript | - | - | - | TSL:3, |
PARP1-206 | ENST00000469663.1 | 542 | No protein | Processed transcript | - | - | - | TSL:3, |
PARP1-212 | ENST00000676685.1 | 6210 | No protein | Retained intron | - | - | - | - |
PARP1-217 | ENST00000677374.1 | 5697 | No protein | Retained intron | - | - | - | - |
PARP1-209 | ENST00000498787.2 | 5629 | No protein | Retained intron | - | - | - | TSL:2, |
PARP1-225 | ENST00000678781.1 | 5430 | No protein | Retained intron | - | - | - | - |
PARP1-226 | ENST00000679276.1 | 4918 | No protein | Retained intron | - | - | - | - |
PARP1-213 | ENST00000676709.1 | 4764 | No protein | Retained intron | - | - | - | - |
PARP1-219 | ENST00000677884.1 | 4620 | No protein | Retained intron | - | - | - | - |
PARP1-218 | ENST00000677815.1 | 3770 | No protein | Retained intron | - | - | - | - |
PARP1-211 | ENST00000676565.1 | 3577 | No protein | Retained intron | - | - | - | - |
PARP1-201 | ENST00000366790.4 | 3358 | No protein | Retained intron | - | - | - | TSL:2, |
PARP1-207 | ENST00000490921.5 | 3165 | No protein | Retained intron | - | - | - | TSL:2, |
PARP1-223 | ENST00000678288.1 | 2420 | No protein | Retained intron | - | - | - | - |
PARP1-204 | ENST00000463968.5 | 830 | No protein | Retained intron | - | - | - | TSL:2, |
PARP1-205 | ENST00000468608.1 | 438 | No protein | Retained intron | - | - | - | TSL:3, |
PARP1-208 | ENST00000491816.1 | 416 | No protein | Retained intron | - | - | - | TSL:2, |
Target Gene | PARP1 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene PARP1 had been KO in hek293t cell line. |
$49
Single gRNA plasmid off-shelf
$599
Single gRNA lentivirus
Please leave your suggestion ×