CRISPR-U™ Gene Knockout Cell Line Strategy

GBP4 Gene Knockout Strategy

CRISPR-U™ technology (CRISPR based), developed by Ubigene, is more efficient than general CRISPR/Cas9 technology in double-strand breaking and homologous recombination. With CRISPR-U™, Ubigene has successfully edited over 3000 genes on more than 100 types of cell lines.
To create a Human GBP4 Knockout model in cell line by CRISPR-U™-mediated genome engineering.
Target gene info
Official symbol GBP4
Gene id 115361
Organism Homo sapiens
Official full symbol guanylate binding protein 4
Gene type protein-coding
Also known as Mpa2
Summary Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 ).
Genomic regions Chromosome 1
Strategy Summary
This gene has 1 protein coding transcripts:
Name Transcript ID bp Protein Biotype CCDS UniProt Match RefSeq Match Flags
GBP4-201 ENST00000355754.7 6141 640aa Protein coding CCDS721 Q96PP9 NM_052941.5 TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92,
GBP4-202 ENST00000471938.1 768 No protein Processed transcript - - - TSL:3,
GBP4-203 ENST00000481397.1 457 No protein Processed transcript - - - TSL:5,
Ubigene Red Cotton Transcript
Strategy Click to get
Red Cotton™ Assessment    
Project Difficulty Level unknown
Target Gene GBP4
This KO Strategy loading
Red Cotton™ Notes Gene GBP4 had been KO in a549 cell line.
Aforementioned information comes from Ubigene database. Different origin of cell lines may have different condition. Ubigene reserved all the right for final explanation.
Special deals for this gene:


Single gRNA plasmid off-shelf


Single gRNA lentivirus

Work flow
Ubigene Red Cotton Workflow

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