CRISPR-U™ Gene Knockout Cell Line Strategy

ADRM1 Gene Knockout Strategy

CRISPR-U™ technology (CRISPR based), developed by Ubigene, is more efficient than general CRISPR/Cas9 technology in double-strand breaking and homologous recombination. With CRISPR-U™, Ubigene has successfully edited over 3000 genes on more than 100 types of cell lines.
To create a Human ADRM1 Knockout model in cell line by CRISPR-U™-mediated genome engineering.
Target gene info
Official symbol ADRM1
Gene id 11047
Organism Homo sapiens
Official full symbol adhesion regulating molecule 1
Gene type protein-coding
Also known as ARM-1, ARM1, GP110
Summary This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants.
Genomic regions Chromosome 20
Strategy Summary
This gene has 4 protein coding transcripts:
Name Transcript ID bp Protein Biotype CCDS UniProt Match RefSeq Match Flags
ADRM1-204 ENST00000491935.5 1530 407aa Protein coding CCDS13496 Q16186 - TSL:5, GENCODE basic, APPRIS P1,
ADRM1-201 ENST00000253003.7 1379 407aa Protein coding CCDS13496 Q16186 NM_007002.4 TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92,
ADRM1-205 ENST00000620230.4 1361 368aa Protein coding CCDS74747 A0A087WX59 - TSL:5, GENCODE basic,
ADRM1-202 ENST00000462554.2 735 141aa Protein coding - A0A087WUX6 - CDS 3' incomplete, TSL:3,
ADRM1-203 ENST00000465805.2 630 No protein Processed transcript - - - TSL:2,
Ubigene Red Cotton Transcript
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Red Cotton™ Assessment    
Project Difficulty Level unknown
Target Gene ADRM1
This KO Strategy loading
Red Cotton™ Notes Gene ADRM1 had been KO in hek293t cell line.
Aforementioned information comes from Ubigene database. Different origin of cell lines may have different condition. Ubigene reserved all the right for final explanation.
Special deals for this gene:


Single gRNA plasmid off-shelf


Single gRNA lentivirus

Work flow
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