CRISPR-U™ Gene Knockout Cell Line Strategy

HMGN4 Gene Knockout Strategy

CRISPR-U™ technology (CRISPR based), developed by Ubigene, is more efficient than general CRISPR/Cas9 technology in double-strand breaking and homologous recombination. With CRISPR-U™, Ubigene has successfully edited over 3000 genes on more than 100 types of cell lines.
To create a Human HMGN4 Knockout model in cell line by CRISPR-U™-mediated genome engineering.
Target gene info
Official symbol HMGN4
Gene id 10473
Organism Homo sapiens
Official full symbol high mobility group nucleosomal binding domain 4
Gene type protein-coding
Also known as HMG17L3, NHC
Summary The protein encoded by this gene, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates.
Genomic regions Chromosome 6
Strategy Summary
This gene has 1 protein coding transcripts:
Name Transcript ID bp Protein Biotype CCDS UniProt Match RefSeq Match Flags
HMGN4-201 ENST00000377575.3 1943 90aa Protein coding CCDS4615 A0A024R046 O00479 NM_006353.3 TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92,
HMGN4-202 ENST00000477243.1 113 No protein Processed transcript - - - TSL:3,
Ubigene Red Cotton Transcript
Strategy Click to get
Red Cotton™ Assessment    
Project Difficulty Level unknown
Target Gene HMGN4
This KO Strategy loading
Red Cotton™ Notes Gene HMGN4 had been KO in hela cell line.
Aforementioned information comes from Ubigene database. Different origin of cell lines may have different condition. Ubigene reserved all the right for final explanation.
Special deals for this gene:


Single gRNA plasmid off-shelf


Single gRNA lentivirus

Work flow
Ubigene Red Cotton Workflow

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