Official symbol | TUBB3 |
Gene id | 10381 |
Organism | Homo sapiens |
Official full symbol | tubulin beta 3 class III |
Gene type | protein-coding |
Also known as | CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, TUBB4, beta-4 |
Summary | This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. |
Genomic regions | Chromosome 16 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
TUBB3-206 | ENST00000554444.5 | 1978 | 378aa | Protein coding | CCDS56012 | Q13509-2 | - | TSL:2, GENCODE basic, |
TUBB3-201 | ENST00000315491.12 | 1706 | 450aa | Protein coding | CCDS10988 | Q13509-1 | NM_006086.4 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
TUBB3-205 | ENST00000554336.5 | 903 | 118aa | Protein coding | - | G3V2R8 | - | TSL:3, GENCODE basic, |
TUBB3-210 | ENST00000555810.5 | 767 | 189aa | Protein coding | - | G3V2A3 | - | CDS 3' incomplete, TSL:3, |
TUBB3-203 | ENST00000553967.1 | 736 | 164aa | Protein coding | - | G3V2N6 | - | TSL:2, GENCODE basic, |
TUBB3-208 | ENST00000555576.5 | 572 | 97aa | Protein coding | - | G3V5W4 | - | TSL:4, GENCODE basic, |
TUBB3-212 | ENST00000556565.5 | 566 | 46aa | Protein coding | - | G3V542 | - | CDS 3' incomplete, TSL:4, |
TUBB3-209 | ENST00000555609.5 | 1855 | 55aa | Nonsense mediated decay | - | G3V3J6 | - | TSL:3, |
TUBB3-211 | ENST00000556536.5 | 925 | 148aa | Nonsense mediated decay | - | G3V3R4 | - | TSL:3, |
TUBB3-213 | ENST00000557262.5 | 888 | 51aa | Nonsense mediated decay | - | G3V4U2 | - | TSL:1, |
TUBB3-214 | ENST00000557490.5 | 806 | 87aa | Nonsense mediated decay | - | G3V3W7 | - | TSL:5, |
TUBB3-202 | ENST00000553656.5 | 550 | 51aa | Nonsense mediated decay | - | G3V4U2 | - | TSL:4, |
TUBB3-204 | ENST00000554116.5 | 542 | No protein | Processed transcript | - | - | - | TSL:4, |
TUBB3-216 | ENST00000680788.1 | 5062 | No protein | Retained intron | - | - | - | - |
TUBB3-215 | ENST00000680647.1 | 2921 | No protein | Retained intron | - | - | - | - |
TUBB3-207 | ENST00000554927.1 | 561 | No protein | Retained intron | - | - | - | TSL:2, |
Target Gene | TUBB3 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene TUBB3 had been KO in hct116 cell line. |
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