CRISPR-U™ Gene Knockout Cell Line Strategy

LANCL1 Gene Knockout Strategy

CRISPR-U™ technology (CRISPR based), developed by Ubigene, is more efficient than general CRISPR/Cas9 technology in double-strand breaking and homologous recombination. With CRISPR-U™, Ubigene has successfully edited over 3000 genes on more than 100 types of cell lines.
To create a Human LANCL1 Knockout model in cell line by CRISPR-U™-mediated genome engineering.
Target gene info
Official symbol LANCL1
Gene id 10314
Organism Homo sapiens
Official full symbol LanC like 1
Gene type protein-coding
Also known as GPR69A, p40
Summary This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Genomic regions Chromosome 2
Strategy Summary
This gene has 7 protein coding transcripts:
Name Transcript ID bp Protein Biotype CCDS UniProt Match RefSeq Match Flags
LANCL1-205 ENST00000443314.5 4781 399aa Protein coding CCDS2392 O43813 Q53TN2 - TSL:1, GENCODE basic, APPRIS P1,
LANCL1-207 ENST00000450366.7 4592 399aa Protein coding CCDS2392 O43813 Q53TN2 NM_006055.3 TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92,
LANCL1-204 ENST00000441020.7 4503 399aa Protein coding CCDS2392 O43813 Q53TN2 - TSL:5, GENCODE basic, APPRIS P1,
LANCL1-201 ENST00000233714.8 1647 399aa Protein coding CCDS2392 O43813 Q53TN2 - TSL:1, GENCODE basic, APPRIS P1,
LANCL1-203 ENST00000431941.6 1270 399aa Protein coding CCDS2392 O43813 Q53TN2 - TSL:1, GENCODE basic, APPRIS P1,
LANCL1-206 ENST00000448951.5 808 196aa Protein coding - E9PHS0 - CDS 3' incomplete, TSL:3,
LANCL1-202 ENST00000412863.1 441 147aa Protein coding - H7C2E3 - CDS 5' and 3' incomplete, TSL:5,
LANCL1-208 ENST00000453956.1 590 82aa Nonsense mediated decay - F8WDS9 - TSL:4,
Ubigene Red Cotton Transcript
Strategy Click to get
Red Cotton™ Assessment    
Project Difficulty Level unknown
Target Gene LANCL1
This KO Strategy loading
Red Cotton™ Notes Gene LANCL1 had been KO in hela cell line.
Aforementioned information comes from Ubigene database. Different origin of cell lines may have different condition. Ubigene reserved all the right for final explanation.
Special deals for this gene:


Single gRNA plasmid off-shelf


Single gRNA lentivirus

Work flow
Ubigene Red Cotton Workflow

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