Official symbol | CDK8 |
Gene id | 1024 |
Organism | Homo sapiens |
Official full symbol | cyclin dependent kinase 8 |
Gene type | protein-coding |
Also known as | IDDHBA, K35 |
Summary | This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. |
Genomic regions | Chromosome 13 |
Name | Transcript ID | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
CDK8-201 | ENST00000381527.8 | 3065 | 464aa | Protein coding | CCDS9317 | P49336-1 | NM_001260.3 | TSL:1, GENCODE basic, APPRIS P1, MANE Select v0.92, |
CDK8-206 | ENST00000625988.1 | 795 | 148aa | Protein coding | - | A0A0D9SEP3 | - | CDS 5' incomplete, TSL:5, |
CDK8-202 | ENST00000465820.6 | 586 | 195aa | Protein coding | - | A0A0D9SFZ2 | - | CDS 5' and 3' incomplete, TSL:3, |
CDK8-205 | ENST00000536792.5 | 3032 | 164aa | Nonsense mediated decay | - | F5H6D4 | - | TSL:1, |
CDK8-204 | ENST00000480323.1 | 1996 | No protein | Retained intron | - | - | - | TSL:2, |
CDK8-203 | ENST00000477277.5 | 1770 | No protein | Retained intron | - | - | - | TSL:3, |
Target Gene | CDK8 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene CDK8 had been KO in hela cell line. |
$49
Single gRNA plasmid off-shelf
$599
Single gRNA lentivirus
Please leave your suggestion ×